Xiaomeng Ren, Xiaofeng Wang, Mengchen Yuan, Chao Tian, Huilong Li, Xinyu Yang, Xinye Li, Yanda Li, Yihan Yang, Nian Liu, Hongcai Shang, Yonghong Gao* and Yanwei Xing* Pages 3062 - 3071 ( 10 )
Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious diseases and is an increasing health-care burden. AF is associated with an excess amount of reactive oxygen species. In this review, we summarize several possible reactive oxygen species pathways that induce AF based on atrial electrical and structural remodeling data. The sources and factors implicated in AF-related oxidative stress include NADPH oxidase activation, calcium overloading and mitochondrial damage, angiotensin system activation, nitric oxide synthase uncoupling, and xanthine oxidase activation-associated cardiovascular conditions. Scavenging oxidative stress markers and related substances are essential aspects of these molecular mechanisms, and may be a therapeutic target in AF.
Oxidative stress, atrial fibrillation, mechanisms, treatments, ROS, angiotensin.
Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, Beijing University of Chinese Medicine, Beijing 100029, Department of Cardiology, Beijing An Zhen Hospital of the Capital University of Medical Sciences, Beijing 100853, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053