Rui Lin*, Shanshan Wang and Wentian Liu Pages 3008 - 3013 ( 6 )
A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications in biotechnology and medicine.
Elastin-like polypeptides, inverse temperature phase transition, drug delivery, protein purification, tissue engineering, endoscopic submucosal injection solution.
Department of Gastroenterology and Hepatology, Tianjin Medical University, General Hospital, Tianjin 300052, School of Biological Science and Engineering, Shanxi University of Technology, Hanzhong 723001, Department of Gastroenterology and Hepatology, Tianjin Medical University, General Hospital, Tianjin 300052