Review Article

Polyphenols, their Metabolites and Derivatives as Drug Leads

Author(s):

A. Filipa Almeida, Claudia Nunes dos Santos and Maria Rita Ventura*   Pages 2188 - 2207 ( 20 )

Abstract:

In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.

Keywords:

Polyphenols, polyphenol metabolites, chemical synthesis, medicinal chemistry, drugs, anticancer.

Affiliation:

Instituto de Tecnologia Quimica e Biologica Antonio Xavier, NOVA - Universidade Nova de Lisboa, Avenida da Republica, 2781- 901 Oeiras, Instituto de Tecnologia Quimica e Biologica Antonio Xavier, NOVA - Universidade Nova de Lisboa, Avenida da Republica, 2781- 901 Oeiras, Instituto de Tecnologia Quimica e Biologica Antonio Xavier, NOVA - Universidade Nova de Lisboa, Avenida da Republica, 2781- 901 Oeiras

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