Nikoletta Papaevgeniou and Niki Chondrogianni* Pages 2107 - 2120 ( 14 )
Polyphenols constitute a group of compounds that have been highly investigated for their beneficial effects against various pathologic and non-pathologic conditions and diseases. Among their multi-faceted properties, their anti-oxidant potential nominates them as ideal protective candidates for conditions characterized by elevated levels of oxidative stress, including aging and age-related diseases. The nematode Caenorhabditis elegans is a multicellular model organism that is highly exploited in studies related to aging and age-associated pathologies. In this review, we will summarize studies where polyphenolic compounds have been tested for their anti-aging potential and their protective role against the progression of age-related diseases using C. elegans as their main model.
Aging, senescence, aggregation, age-related diseases, C. elegans, polyphenols, longevity, stress resistance.
Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens