Goo Yong Chung, Kyou Hee Shim, Hye Jin Kim, Seul Ki Min and Hwa Sung Shin* Pages 1859 - 1864 ( 6 )
The time window for neuroprotection during ischemic brain stroke is short, and hence, development of neuroprotectants is critical to extend this time window. This study sought to verify if muco-adhesive chitosan coating improves the neuroprotective potential of the pre-proven C-Phycocyanin-pertaining liposome (C-Pc liposome). The use of chitosan-coated liposomes extended the neuroprotective time window by 6 h after occlusion, and further improved the neuroprotection efficiency of the C-Pc liposome in a rat Middle Cerebral Artery Occlusion (MCAO) model. Beneficial changes in mRNA expressions of antioxidants, inflammatory cytokines and glia scar proteoglycans were evident in the C-Pc liposomes. In addition, in the cultured astrocytes, the chitosan- coated C-Pc liposome expressed anti-oxidative activity without cytotoxicity.
Chitosan, C-phycocyanin, neuroprotection, liposome, ischemia and reperfusion, brain stroke.
Department of Biological Engineering, Inha University, Incheon, 22212, Department of Biological Engineering, Inha University, Incheon, 22212, Department of Biological Engineering, Inha University, Incheon, 22212, Department of Biological Engineering, Inha University, Incheon, 22212, Department of Biological Engineering, Inha University, Incheon, 22212