Guilherme Felipe dos Santos Fernandes, Aline Renata Pavan and Jean Leandro dos Santos* Pages 1325 - 1340 ( 16 )
Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxides are described herein, nevertheless, the following chemical classes deserve to be highlighted due to a large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide. In order to describe those most promising compounds, we included in this review only those most biologically active heterocyclic Noxide published since 2000.
Heterocyclic N-oxides, N-oxide compounds, tuberculosis, malaria, neglected tropical diseases, leishmaniasis, Chagas disease, drug discovery.
Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara