Ling Gui Ning, En-Tang Kang, Yun Bing Wang, Xue Feng Hu* and Li Qun Xu* Pages 911 - 925 ( 15 )
Traditional use of antibiotics through injection or oral ingestion has many disadvantages, such as detrimental side effects in the host, less effectiveness, high and repeated doses, and development of drug resistance. For prevention and treatment of implant-associated infections, the continuous local delivery of antibiotics is required. Thus, there is a strong demand for the development of drug carrier systems to control the release of antibiotics in a moderate manner over an appropriate timescale. This review summarizes the carrier platforms used for the loading of antibiotics, and highlights their drug release behaviors as well as in vitro and in vivo antibacterial properties.
Antibiotics, controlled release systems, bacterial infection, drug resistance, implants, drug carrier systems.
Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, 117576, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715