Soledad Lorena Saavedra*, Lucia Avila, Silvana Laura Giudicessi, Fernando Albericio, Silvia Andrea Camperi, Osvaldo Cascone and Maria Camila Martinez-Ceron* Pages 1737 - 1747 ( 11 )
Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents. However, access to antivenom obstructs the successful implementation of the World Health Organization international guidelines. In the last few years, natural organic compounds, peptides, and proteins with the ability to inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2 and metalloproteinases, and their application as novel antivenoms.
Antivenom, protein, plant extracts, peptides, inhibition, metalloproteinases, phospholipase A2.
Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires, Instituto Nacional de Produccion de Biologicos, ANLIS-Malbran, Av. Velez Sarsfield 563, 1282, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires, Department of Organic Chemistry, University of Barcelona, Marti i Franques 1-11, 08028 Barcelona, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires, Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Catedra de Biotecnologia, Junin 956, 1113, Buenos Aires