Tristan Pascart* and Pascal Richette Pages 684 - 689 ( 6 )
Despite the fact that colchicine is by far the most ancient treatment for gout, new data are still being gathered. In gout, colchicine's ability to block polymerization of tubulin prevents the activation of the inflammasome. Efficacy of colchicine for the treatment of gout flares has been demonstrated only recently by a randomized- controlled trial, but it still has not been compared to other drugs. Use of colchicine is impaired by the impact of underlying comorbid conditions and drug interactions that can considerably modify its pharmacokinetics and pharmacodynamics. This manuscript reviews the state-of-the-art of colchicine in gout, from its known mechanisms of action to its effects, wanted and unwanted, expected and unexpected.
Colchicine, gout, tubulin, drugs, pharmacokinetics, pharmacodynamics.
Department of Rheumatology, Lille Catholic Hospitals, University of Lille, F-59160 Lomme, INSERM U1132 and University Paris-Diderot, Paris