Chongshan Liao, Chengfei Zhang and Yanqi Yang* Pages 6302 - 6309 ( 8 )
Bone remodelling is a strictly regulated dynamic process between bone resorption and bone formation. Many factors are involved in the process and affect the dynamic balance. Inflammation-mediated bone loss is a major feature of various bone diseases, including periodontitis, rheumatoid arthritis (RA) and spondyloarthritis (SpA). Interleukin-17 (IL-17) plays an important role in inflammatory bone disease and could be an attractive therapeutic target. This review focuses on the osteoclastic effects of IL-17 in different cell types and summarizes the current knowledge of IL-17 signalling pathways. Typical IL-17–mediated bone destruction disorders are examined. The review also provides an overview of possible strategies for therapeutic intervention for inflammatory loss of bone targeting IL-17.
IL-17, IL-17 receptor, bone loss, osteoclastogensis, RANKL, osteoclasts.
Orthodontics, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong SAR, Endodontology, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong SAR, Orthodontics, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong SAR