Javed Ahmad*, Madhur Singhal, Saima Amin, Md. Rizwanullah, Sohail Akhter*, Mohammad Amjad Kamal, Nafis Haider, Patrick Midoux and Chantal Pichon Pages 1575 - 1588 ( 14 )
With the advent of novel vesicular drug delivery systems especially bilosomes, for large molecular weight proteins and peptides, their oral administration seems a viable approach. These nano-vesicles have shown promising results for the effective delivery of insulin and other therapeutics, perhaps due to their structural composition. The present review has elaborated the biopharmaceutical challenges for the oral delivery of therapeutic proteins and peptides as well as presented a novel approach to deliver the essential macromolecules through oral route as bilosomes. The extensive search has been presented related to the formulation, evaluation and in vivo performance of bilosomes. Some of the crucial findings related to bilosomes have corroborated them superior to other colloidal carriers. The successful drug delivery through bilosomes requires significant justifications related to their interaction with the biological membranes. The other aspects such as absolute absorption, safety and toxicity of bilosome drug delivery should also be equally considered.
Biopharmaceuticals, bilosomes, proteins and peptides, oral delivery, lymphatic transport.
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, UP-229010, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire Region, Metabolomics & Enzymology Unit, Fundamental and Applied Biology Group, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Prince Sultan Military College of Health Sciences, King Fahad Military Medical Complex, Dhahran-31932, Centre de Biophysique Moléculaire, CNRS UPR4301, Orleans, Centre de Biophysique Moleculaire, CNRS UPR4301, Orleans