Laura de Ramon, Marta Jarque, Elia Ripoll, Oriol Bestard, Josep M. Grinyo and Juan Torras Pages 4651 - 4657 ( 7 )
Background: Ischemia reperfusion injury is an important pathophysiological process in many fields such as transplantation, stroke, atherosclerosis, trauma and myocardial infarction. Recent advances in gene silencing may help to reduce ischemic effects, targeting molecules related to this pathological process. Methods and results: Here, we review the different silencing approaches in ischemic injury, highlighting the role of co-stimulatory molecules in renal transplantation. Conclusion: Gene silencing appears as a new strategy to prevent the inflammation and injury associated with ischemia.
Ischemia, siRNA, gene silencing, CD40.
, , , , , xperimental Nephrology, Departament de Ciències Clíniques, Universitat de Barcelona, Institut d’investigació biomedica de Bellvitge (IDIBELL), Hospitalet Llobregat, Barcelona, Spain.