Vitor Francisco Ferreira, Caroline Deckmann Nicoletti, Patricia Garcia Ferreira, Debor Omena Futuro and Fernando de Carvalho da Silva Pages 5899 - 5914 ( 16 )
Quinones are among the most studied natural and synthetic products in the literature because they have considerable biological potential. These compounds exhibit activity against many microorganisms and are able to eliminate tumor cells through several mechanisms of action. Some of these compounds have become drugs that are used clinically. However, they also have problems with respect to solubility, stability and toxicity. The alternative of using controlled-release systems has been applied to quinones, with good results in some cases, indicating that these formulations may be a strategy for improving the pharmacological profile of this class of compounds.
Anticancer compounds, β-lapachone, naphthoquinones, controlled-release systems, formulations
Universidade Federal Fluminense, Instituto de Química, Campus do Valonguinho, 24020-150 Niterói, RJ, Brazil.