Victor V. Uteshev, Olli Tenovuo and Nikhil Gaidhani Pages 2083 - 2092 ( 10 )
Existing treatments of traumatic brain injury (TBI) have failed to reverse tremendous losses in productivity, independence and overall quality of life among TBI victims and therefore, cannot be viewed as sufficient. Although there is no shortage of promising basic concepts that may translate to efficacious therapies after TBI, the accumulated knowledge has yet to deliver treatments that adequately meet clinical and social demands. In this article, we discuss novel concepts, recent advances and accompanying challenges in developing cholinergic and related therapies after TBI.
Trauma, brain, injury, cholinergic, nicotinic, acetylcholine, vagus, vagal, stimulation, inflammatory, immune.
University of North Texas Health Science Center, Institute for Healthy Aging, Center for Neuroscience Discovery, Fort Worth, TX 76248, USA.