C. L. Schlichting, W. D. Schareck and M. Weis Pages 171 - 181 ( 11 )
Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.
autoimmunity,dendritic cells,endothelium,endothelial cell,migration,inflammation
, , Department of Surgery, Devision of Transplantation Surgery, School of Medicine, UniversityHospital, University Rostock, Schillingalle 35, 18055 Rostock, Germany.