A. Jennings and M. Tennant Pages 335 - 344 ( 10 )
Small research-based pharmaceutical start-ups often lack the budget and do not have the infrastructure available to apply all possible techniques for compound selection. This review details our use of a range of techniques such as high-throughput docking and similarity searching to maximize the success rate when attempting to identify pharmaceutically relevant ligands in a resource-constrained environment.
docking methods,murein synthetic pathway,enzymes,murb assay,diversity metrics,pharmacophore
, Syrrx, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.