Call for Papers  

Article Details


Uric Acid and the Kidney: Urate Transport, Stone Disease and Progressive Renal Failure

[ Vol. 11 , Issue. 32 ]

Author(s):

G. Capasso, Ph. Jaeger, W. G. Robertson and R. J. Unwin   Pages 4153 - 4159 ( 7 )

Abstract:


In this brief review and update, we try to cover recent developments in our understanding of uric acid transport by the kidney, the contribution of uric acid to renal stone disease, its potential role in progressive renal failure and, most recently, the novel and as yet unexplained link between the urinary glycoprotein Tamm-Horsfall protein (uromodulin) and hyperuricaemia and two inherited forms of renal disease with chronic renal failure.

Keywords:

Kidney,uric acid,urate transport,nephrolithiasis,renal failure,Tamm-Horsfall protein,uromodulin

Affiliation:

, , , Centre for Nephrology (Department of Physiology), Royal Free and University College MedicalSchool (University College London), Royal Free Campus, Rowland Hill Street, London NW3 2PF UK.



Read Full-Text article