Ilma Rita Korponay-Szabo, Zsofia Simon-Vecsei, Luigina De Leo and Tarcisio Not Pages 5753 - 5758 ( 6 )
Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects. Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.
Genetic gluten intolerance, intestinal anti-transglutaminase antibodies, auto-immunity
Department of Pediatrics, University of Debrecen, Nagyerdei krt 98, H-4012 Debrecen, Hungary.