J. Martin, S. Collot-Teixeira, L. McGregor and J. L. McGregor Pages 1751 - 1759 ( 9 )
The aim of this chapter is to present and identify potential pharmacological targets in endothelial cell-monocyte interactions leading to vascular syndrome and involving inflammation, coagulation, vascular remodelling and thrombosis. Increasing evidence is indicating that endothelial cells play a key role in atherothombosis by their capacity to attract, bind and allow the extravasation of monocytes to sites of inflammation. Surface expression and/or activation of constituent cell adhesion molecules (for e.g. P-selectin, E-selectin, ICAM-1, and VCAM-1) on endothelial cells together with chemokines such as CXCL8 (IL-8), Platelet-activating factor (PAF), CCL2 and CCL5 (Table 1) allow the rolling, adhesion and extravasation of monocytes. This review focuses on pharmacological targets implicated in endothelial cells interactions with monocytes/macrophages in vascular disease states and on cutting edge genomic tools for the identification and characterization of such targets.
Inflammation,endothelial cells,monocytes/macrophages,cell adhesion molecules,chemokines,polymorphisms,genomic tools
, , , Thrombosis Research Institute,Genomics&Atherothrombosis Laboratory, Manresa Road, London SW3 6LR, London, UK.