J. M. Tarr, P. Eggleton and P. G. Winyard Pages 4445 - 4468 ( 24 )
Nitric oxide (NO) is a small, highly reactive, diffusible free radical which has been implicated in many physiological and pathophysiological processes. It has either pro-apoptotic or anti-apoptotic effects on cells, depending upon a host of factors. This review outlines some of the regulatory molecules and organelles involved in the apoptotic pathways that can be influenced by the presence of NO, including p53, Bcl-2, caspases, mitochondria, and heat shock proteins. The effects of NO on the apoptosis of tumour cells are also examined.
Nitric Oxide,Apoptosis,Nitric Oxide Synthase,Tumour Cells
, , Institute of Biomedical and Clinical Science, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, Devon, EX1 2LU, UK.