Chewki Ziani-Cherif, Bachir Mostefa-Kara and Fatima Z. Brixi-Gormat Pages 4313 - 4335 ( 23 )
Alzheimer disease (AD) is characterized by excessive deposition of amyloid β-peptides (Aβ peptides) in the form of senile plaques as well as neurofibrillary tangles (NFTs) in the brain. In the amyloidogenic pathway, the amyloid-β precursor protein (APP) is cleaved by β-secretase first, followed by γ-secretase cleavage producing therefore Aβ. This review summarizes the recent findings in the AD field and focuses on the different γ-secretase inhibitors that have been developed as a therapeutic approach toward AD.
Alzheimer disease,amyloid βprecursor protein,amyloid β,γ-secretase,presenilins,γ-secretase inhibitors,nonsteroidal anti-inflammatory drugs
, , Laboratoire de Catalyse et Chimie Fine, Université Abou Bekr Belkaid, B.P. 119, Tlemcen 13000, Algeria.