Adam Lesner, Anna Legowska, Magdalena Wysocka and Krzysztof Rolka Pages 4308 - 4317 ( 10 )
This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
SFTI-1,inhibitor,serine proteinases,peptidomimetics,peptomers,analogs,pharmaceutical agents,cytotoxicity,trypsin,chymotrypsin
, , , Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland.