P. Clezardin and M. Massaia Pages 3007 - 3014 ( 8 )
Bisphosphonates, especially nitrogen-containing bisphosphonates (N-BPs), are widely used to block bone destruction in cancer patients with bone metastasis because they are effective inhibitors of osteoclast-mediated bone resorption. In addition to their antiresorptive effects, preclinical evidence strongly suggests that N-BPs have anticancer activity. Some of the activities associated with N-BPs are observed in human γδ T cells that straddle the interface of innate and adaptive immunity and have potent anti-tumour activity. This review examines the molecular and cellular mechanisms through which N-BPs stimulate the expansion and cytotoxic activity of human γδ T cells. In addition, we discuss the emerging clinical evidence that N-BPs have a role in cancer immunotherapy.
Bisphosphonate,zoledronate,IPP,gamma delta T cell,immunotherapy,cancer,Cancer Immunotherapy,nitrogen-containing bisphosphonates (N-BPs),osteoclast-mediated bone resorption,sorptive effects,T cells,mevalonate path-way,isoprenoid lipids,farnesyl pyrophosphate synthase (FPPS),GTPases,monocytes,macrophages,endothelial,tumour cells,adaptive immunity,Innate immunity,macro-phages,antigen-targeted cytotoxic cells,histocompatibil-ity complex (MHC),farnesyl pyrophosphate (FPP),tumour antigen,phosphoantigens,cytokines,Tregs' activity,pa-midronate, risedronate,immunostimulatory properties,antigen-presenting cells,peripheral blood mononuclear cells (PBMC),putative antigen-presenting molecule,nonhuman antigen-presenting,cytolytic granules,anti-tumour activity,chronic myelogenous leukemic cells,autologous,kemia cells,allogeneic,zoledronate-treated,myeloid leukemia,CANCER IMMUNO-THERAPY,antigen-recognition properties,a synthetic phosphoantigen,pleiotropic pharmaceutical agents,tumor-hostile counterpart,goserelin,tamoxifen,anastrozole,endocrine-responsive,multichemotherapy,chemorefractory adrenocortical carcinoma
, 1INSERM, Research Unit U664, University of Lyon-1, Faculty of Medicine Laennec, rue Guillaume Paradin, 69372 Lyon cedex 08, France, 2Laboratorio di Ematologia Oncologica,Centro di Ricerca in Medicina Sperimentale (CeRMS), and Divisione Universitaria di Ematologia, Ospedale San Giovanni Battista di Torino ed Universita' degli Studi di Torino, Torino, Italy, via Genova 3, 10126 Torino, Italy.