Muhammad Naseem, Hummera Rafique*, Sadia Roshan, Zaman Ashraf, Fouzia Perveen and Muhammad Tayyab Pages 1078 - 1086 ( 9 )
Introduction: An efficient and four-component one-pot facile synthesis of tetra-substituted imidazole is achieved by cyclo-condensation reaction of benzil with subsequent successive substitution of aromatic aldehydes, ester substituted amine and ammonium acetate via refluxing the mixture for almost two hours at 140°C.
Method: The ending point of the understudy reaction was examined by TLC after regular intervals. Synthesized 1,2,4-tetrasubstituted imidazoles were characterized by physical data and the structural features were analyzed using spectroscopic techniques such as FTIR, NMR and elemental analysis.
Results: The inhibition potential of fabricated compounds was evaluated against the mushroom based Tyrosinase (polyphenol oxidase) enzyme. Tetra-substituted imidazole derivatives demonstrated significant potent tyrosinase inhibition activities.
Conclusion: Pharmacokinetic mechanism and molecular docking studies were also carried out.
One-pot synthesis, biological activities, molecular docking, pharmacokinetic studies, mushroom tyrosinase inhibitors, aromatic aldehydes.