Samaneh Mollazadeh, Nikoo Saeedi, Abdulridha Mohammed Al-Asady, Elnaz Ghorbani, Majid Khazaei, Mikhail Ryzhikov, Amir Avan* and Seyed Mahdi Hassanian* Pages 432 - 442 ( 11 )
Hepatocellular carcinoma (HCC) is influenced by several factors, among which genetic polymorphisms play a key role. Polymorphisms in various genes affect key pathways involved in HCC development, including metabolism, expression of inflammatory cytokines, cell proliferation, and apoptosis regulation. These polymorphisms induce differential effects on susceptibility to HCC, disease progression, and treatment outcomes. Understanding the effect of genetic variations on HCC pathogenesis is essential to elucidate underlying mechanisms and identify potential therapeutic targets. This review explores the diverse roles of genetic polymorphisms in HCC, providing insights into the complex interplay between genetic factors and disease development.
Genetics, polymorphism, liver cancer, proliferation, apoptosis, hepatocellular carcinoma.