S. Fulda Pages 430 - 435 ( 6 )
Evasion of apoptosis, the cells intrinsic death program, is a hallmark of human cancers including neuroblastoma. Also, failure to undergo apoptosis may cause treatment resistance, since the cytotoxic activity of anticancer therapies commonly used in the clinic, e.g. chemotherapy, γ-irradiation or immunotherapy, is predominantly mediated by triggering apoptosis in tumor cells. Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma.
Apoptosis,neuroblastoma,TRAIL,caspase-8,Bcl-2,IAPs
University Children's Hospital, Eythstr. 24, D-89075 Ulm, Germany.