Yong Cui, Yapeng Hou, Honglei Zhang, Yanhong Liu, Kejun Mao, Hongguang Nie and Yan Ding* Pages 833 - 839 ( 7 )
Edema is a gradual accumulation of fluid in the interstitial tissues or luminal cavities, which is regulated by ion transport pathways and reflects dysfunction of fluid and salt homeostasis. Increasing evidence suggests that some herbal monomers significantly reduce organ/tissue edema. In this review, we briefly summarized the electrolyte permeability involved in pathomechanisms of organ edema, and the benefits of herbal monomers on ionic transport machinery, including Na+-K+-ATPase, Na+ and Cl- channels, Na+-K+-2Cl- co-transporter, etc. Pharmaceutical relevance is implicated in developing advanced strategies to mitigate edematous disorders. In conclusion, the natural herbal monomers regulate electrolyte permeability in many edematous disorders, and further basic and clinical studies are needed.
Herbal monomers, edema, ion channels, electrolyte permeability, epithelium, ionic transport machinery.
Department of Anesthesiology, the First Affiliated Hospital of China Medical University, Shenyang, Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang, Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang