Alamgeer, Hira Asif , Muhammad Z.A. Sandhu, Madiha Aziz, Hafiz M. Irfan, Karyne G.T. Moreno and Arquimedes Gasparotto Junior* Pages 2574 - 2582 ( 9 )
Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors that are involved in the disease. The present review discusses our current knowledge of the major cellular and molecular mechanisms of phytotherapeutics for the treatment of atherosclerosis. Numerous studies have evaluated the antiatherosclerotic activity of phytoconstituents to provide preliminary evidence of efficacy, but only a few studies have delineated the underlying molecular mechanisms. Plant-derived phytotherapeutics primarily targets abnormal levels of lipoproteins, endothelial dysfunction, smooth muscle cell migration, foam cell development, and atheromatous plaque formation. Nonetheless, the principal mechanisms that are responsible for their therapeutic actions remain unclear. Further pharmacological studies are needed to elucidate the underlying molecular mechanisms of the antiatherosclerotic response to these phytoconstituents.
Phytoconstituents, antiatherosclerotic, endothelial dysfunction, plaque formation, phytotherapeutics, atheromatous.
Punjab University College of Pharmacy, University of the Punjab, Lahore, Punjab University College of Pharmacy, University of the Punjab, Lahore, Punjab University College of Pharmacy, University of the Punjab, Lahore, Punjab University College of Pharmacy, University of the Punjab, Lahore, Punjab University College of Pharmacy, University of the Punjab, Lahore, Laboratory of Cardiovascular Research and Integrative Pharmacology, College of Pharmacy, University of Sargodha, Sargodha, Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS