Manouchehr Saljoughian and Philip G. Williams Pages 1029 - 1056 ( 28 )
The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.
, The National Tritium Labelling Facility, Physical Biosciences Division, Mailstop 75-123, E.O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA.