Ning Sun , Dongli Li , Xiaoqing Chen, Panpan Wu , Yu-Jing Lu , Ning Hou*, Wen-Hua Chen* and Wing-Leung Wong* Pages 3740 - 3750 ( 11 )
Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.
Oleanolic acid, Pentacyclic triterpenoids, cardioprotective agents, cardiovascular diseases, hepatic drug, asiaticoside.
The State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, Goldenhealth Biotechnology Co. Ltd, Foshan 528000, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, The State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong